Amlodipine Hydrochlothiazide Tablet

ROOTOPINE H

Amlodipine 5 mg and Hydrochlorothiazide 12.5 mg Tablets

Division: DIABGLYM

Composition

Each tablet contains:

Amlodipine Besylate IP equivalent to Amlodipine — 5 mg

Hydrochlorothiazide IP — 12.5 mg

Excipients — q.s.

Colour: Approved colour used

Dosage form: Oral tablet

Product Description

ROOTOPINE H is a synergistic antihypertensive combination of Amlodipine 5 mg and Hydrochlorothiazide 12.5 mg, formulated for the effective management of hypertension and long-term cardiovascular risk reduction. This combination provides dual blood pressure control through complementary mechanisms by combining the vasodilatory action of Amlodipine with the diuretic effect of Hydrochlorothiazide, resulting in enhanced antihypertensive efficacy and improved blood pressure control.

Amlodipine is a long-acting dihydropyridine calcium channel blocker that relaxes vascular smooth muscle, reduces peripheral vascular resistance, and provides sustained 24-hour blood pressure control. Hydrochlorothiazide is a thiazide diuretic that promotes sodium and water excretion, reduces plasma volume, decreases peripheral vascular resistance, and enhances the antihypertensive effect of Amlodipine.

ROOTOPINE H is particularly beneficial in patients with hypertension requiring combination therapy, elderly hypertensive patients, isolated systolic hypertension, hypertension associated with diabetes, obesity, metabolic syndrome, and patients inadequately controlled with monotherapy.

Technical Knowledge of Amlodipine and Hydrochlorothiazide

Amlodipine inhibits L-type calcium channels in vascular smooth muscle, resulting in peripheral arterial vasodilation, reduced systemic vascular resistance, decreased afterload, and improved coronary blood flow. Its long elimination half-life provides effective once-daily blood pressure control.

Hydrochlorothiazide acts on the distal convoluted tubule of the nephron, inhibiting sodium-chloride reabsorption and increasing urinary excretion of sodium, chloride, and water. Long-term therapy reduces peripheral vascular resistance and contributes to sustained blood pressure reduction.

The combination of Amlodipine and Hydrochlorothiazide provides complementary antihypertensive mechanisms, allowing better blood pressure control while minimizing dose-related adverse effects associated with individual agents.

Mechanism of Action

Amlodipine relaxes vascular smooth muscle, reduces peripheral vascular resistance, lowers afterload, improves coronary blood flow, and provides sustained antihypertensive action.

Hydrochlorothiazide promotes sodium and water excretion, reduces plasma volume, decreases peripheral vascular resistance, and enhances the antihypertensive effect of combination therapy.

Key Benefits

Effective reduction of systolic and diastolic blood pressure

Dual antihypertensive mechanism

Sustained 24-hour blood pressure control

Reduces peripheral vascular resistance

Helps control fluid-related hypertension

Improves cardiovascular protection

Enhances blood pressure control compared with monotherapy

Suitable for once-daily long-term hypertension management under medical supervision

Clinical Applications

ROOTOPINE H is commonly prescribed for essential hypertension, uncontrolled hypertension requiring combination therapy, isolated systolic hypertension, hypertension in elderly patients, hypertension with diabetes, hypertension with obesity, hypertension with metabolic syndrome, and long-term cardiovascular risk reduction.

Facts About Amlodipine and Hydrochlorothiazide

Amlodipine is one of the most widely prescribed calcium channel blockers due to its excellent efficacy, long duration of action, and favorable tolerability profile. Hydrochlorothiazide is a well-established thiazide diuretic that has been extensively studied in hypertension management and cardiovascular outcome trials. The combination is widely recommended for patients requiring dual antihypertensive therapy and improved blood pressure control.

Key Facts

Dual antihypertensive combination therapy

Calcium channel blocker and thiazide diuretic combination

Provides sustained 24-hour blood pressure control

Effective in hypertension requiring combination therapy

Reduces vascular resistance and fluid-related blood pressure elevation

Evidence-based antihypertensive combination therapy

Quality-assured pharmaceutical formulation

PCD Pharma Franchise Opportunity

ROOTOPINE H is an excellent product for PCD Pharma Franchise, Cardiology Franchise, and Cardio-Diabetic Franchise across India. The increasing prevalence of hypertension, diabetes, obesity, and cardiovascular disorders creates strong prescription demand and long-term market potential for this combination.

Why Choose ROOTOPINE H for PCD Pharma Franchise?

High prescription potential

Strong physician and cardiologist acceptance

Attractive monopoly franchise opportunity

Competitive pricing

Promotional support available

Visual aids and marketing inputs

Consistent product quality

Excellent repeat business potential

Third Party Manufacturing

Chemsroot Pharmaceutical offers Third Party Manufacturing of Amlodipine 5 mg and Hydrochlorothiazide 12.5 mg Tablets with complete manufacturing support for pharmaceutical companies, marketers, exporters, and franchise businesses.

Our Third Party Manufacturing Services Include

Private label manufacturing

Contract manufacturing

Custom brand manufacturing

Loan license manufacturing

DCGI-compliant production

GMP-certified manufacturing

Batch manufacturing documentation

Product registration support

Customized packaging and artwork

Monopoly franchise packaging

Bulk manufacturing capability

Manufacturing Features

Pharmaceutical-grade raw materials

IP/BP/USP quality standards

In-process quality control

Finished product testing

Stability-oriented formulation

Moisture-controlled tablet manufacturing

Blister and Alu-Alu packaging options

ROOTOPINE H from DIABGLYM combines sustained blood pressure control, effective diuretic support, comprehensive cardiovascular protection, and high-quality pharmaceutical manufacturing, making it an ideal product for physicians, cardiologists, diabetologists, PCD Pharma Franchise partners, and Third Party Manufacturing clients seeking a reliable and evidence-based antihypertensive combination.